Natera

We are a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health.

Senior Bioinformatics Engineer

EngineerEngineerFull TimeRemoteTeam 1,001-5,000Since 2004H1B SponsorCompany SiteLinkedIn

Location

United States

Posted

17 days ago

Salary

$133.3K - $166.6K / year

Postgraduate DegreeEnglishAWSCloudDockerLinuxNumpyPandasPythonScikit LearnShell Scripting

Job Description

• Architect, develop, and maintain scalable, production-ready bioinformatics pipelines for next-generation sequencing data, with primary ownership of workflows implemented in Nextflow and WDL • Lead pipeline design decisions with a strong emphasis on modularity, reusability, robustness, scalability, and maintainability • Refactor and optimize existing pipelines to improve performance, cost efficiency, fault tolerance, and ease of extension • Establish and enforce best practices for workflow development, including parameterization, versioning, provenance tracking, and reproducibility • Design and implement comprehensive testing strategies for pipelines and supporting code, including unit, integration, and end-to-end tests • Deeply understand and troubleshoot complex sequencing data processing pipelines across multiple stages (QC, alignment, methylation calling, feature generation, etc.) • Partner closely with Research, Machine Learning, and Platform Engineering teams to transition research workflows into production-grade systems • Support training and evaluation of machine learning models by enabling efficient data generation and large-scale distributed execution on AWS • Participate in and lead code reviews and design reviews, mentoring other engineers and scientists on workflow and software engineering best practices • Contribute to pipeline documentation, onboarding materials, and internal standards.

Job Requirements

  • MS or PhD in Computer Science, Bioinformatics, Computational Biology, or a related field, with a strong focus on cancer genomics or epigenomics
  • Extensive hands-on experience developing bioinformatics pipelines using Nextflow and/or WDL, including complex multi-step NGS workflows
  • Proven track record of building and supporting production-level bioinformatics software in regulated or high-reliability environments
  • Deep understanding of software engineering best practices, including workflow design patterns, testing, version control, CI/CD, code review, and documentation
  • Strong experience with containerized workflows (Docker) and execution on cloud platforms; AWS experience strongly preferred
  • Expertise in distributed and parallel computing, including workflow execution engines and cloud-native scaling strategies
  • Experience profiling and optimizing pipelines and code for runtime, memory usage, and cost efficiency
  • Strong understanding of sequencing technologies and data types, particularly methylation and epigenomic assays
  • Advanced programming skills in Python, including experience with scientific and data-processing libraries (e.g., Pandas, NumPy, scikit-learn)
  • Expert-level proficiency with Linux, shell scripting, and command-line bioinformatics tools
  • Ability to work independently, lead technical initiatives, and manage multiple priorities in a fast-paced environment
  • Strong communication skills and a collaborative mindset.

Benefits

  • Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

Related Categories

Related Job Pages

More Engineer Jobs

Full TimeRemoteTeam 1,001-5,000Since 1908H1B Sponsor

Senior Project Engineer leading energy storage, solar, transmission, and substation projects

United States
$100.6K - $145.8K / year

Engineer 3

SOLV Energy

We believe good energy has a ripple effect.

Engineer18 days ago
Full TimeRemoteTeam 501-1,000H1B Sponsor

Engineer 3 acting as a Subject Matter Expert for utility-scale EPC projects

United States
$112.7K - $135.2K / year
Full TimeRemoteTeam 10,001+Since 1858H1B Sponsor

Senior Technical Engineer developing enterprise-level production solutions

.NET
Idaho
$71.1K - $145.9K / year

Project Development Engineer

Ameresco

Ameresco, Inc. is a leading cleantech integrator and renewable energy asset developer, owner and operator.

Engineer18 days ago
Full TimeRemoteTeam 1,001-5,000Since 2000H1B Sponsor

Project Development Engineer managing energy efficiency solutions at Ameresco

Colorado
$126.5K - $155.1K / year