• Develop and maintain an integrated, data-driven portfolio strategy aligned with corporate vision and scientific priorities • Lead portfolio review processes, ensuring timely, evidence-based decision-making and clear resource allocation across programs • Evaluate and prioritize internal programs and external opportunities, including partnerships, licensing deals, and platform extensions • Conduct scenario planning, risk assessments, and investment trade-off analyses to guide strategic direction • Oversee or directly lead key development programs spanning discovery, preclinical, and clinical stages • Drive creation and execution of integrated, cross-functional program plans encompassing research, translational, clinical, regulatory, CMC, and commercial considerations • Ensure programs meet timelines, budgets, and milestones; actively identify risks, dependencies, and mitigation strategies • Maintain transparent reporting systems and dashboards for executive leadership, governance committees, and the board • Partner with Research, across Clinical Development functions, and with other internal teams to ensure alignment and operational excellence • Facilitate clear communication and decision-making across all program teams • Support readiness for key milestones such as IND submissions, clinical trial initiations, regulatory interactions, and strategic partnerships • Together with the CMO, establish and refine clinical development team and governance frameworks that enable efficient and high-quality development activities, clear decision-making structures, that facilitate clear communication and a documented alignment in R&D strategy • Build and mentor a high-performing PPM function tailored to the needs of a small, rapidly growing biotech • Implement best practices in project planning, resource management, and cross-functional communication • Champion a culture of accountability, transparency, and collaboration across the organization