Job Description Job Summary: Vertex is seeking a talented and motivated individual with the desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. The role is as a Director within the Modeling Center of Excellence (CoE), a designated group within the HEOR team that provides strategic and technical modeling support to HEOR, Market Access & Pricing, and the broader commercial organization. The main responsibility of the Director will be to lead the team that supports the HEOR disease/asset teams in developing health economic models, including models that will provide the foundations for HTA submissions, as well as early models to inform evidence generation needs. The Director will set the direction for modeling strategy across one or more therapeutic areas or pipeline assets. The Director will provide input into global product value strategy and tactics as well as input to design and interpretation of post-hoc clinical trial analyses and evidence generation studies that relate to economic models. The role has flexibility to be in-person, hybrid, or remote. Key Responsibilities: Set the direction for modeling strategy across one or more therapeutic areas or pipeline assets Provide leadership and support to the HEOR Modeling team as they develop and roll out economic models to support product value strategy Lead the development of global cost-effectiveness and budget impact models, and associated materials. The work may involve both in-house "hands-on" development of models (de novo programming) as well as management and quality assurance and validation of work conducted by external vendors Conduct model trainings and provide support to regional teams in local adaptation process and development of HTA submissions, as well as continued support during negotiations with reimbursement authorities Provide thought leadership on economic modeling to support development of strategic plans and evidence generation activities Provide input into design and interpretation of evidence generation studies needed to support economic models Provide subject matter expertise/knowledge to cross-functional partners to support understanding and appropriate application of relevant HEOR evidence in support of access/reimbursement Present research findings at scientific congresses, participate in development of high-quality publications for peer-review Minimum Qualifications: Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com