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Role Description

The position will contribute to two complementary research projects:

• Develop a computational framework to identify low-quality cells that exhibit cross-modality mismatches in single-cell multi-omics data.
• Develop a statistical methodology for integrative analysis of multi-sample single-cell multi-omics data.

The appointee will lead the design and implementation of novel computational and statistical methods for single-cell multi-omics analysis. Responsibilities include:

• Developing a robust framework to detect low-quality cells exhibiting cross-modality inconsistencies.
• Creating scalable statistical methodologies for integrative analysis across multiple samples.
• Building, documenting, and maintaining associated software packages.
• Curating and preprocessing large-scale real-world datasets.
• Conducting comprehensive benchmarking to rigorously evaluate performance across diverse experimental settings.
• Applying these methods to investigate gene regulatory programs related to aging and cellular senescence.

Qualifications

• Master’s degree in statistics, biostatistics, or a closely related quantitative field.
• Demonstrated expertise in genomics, computational data analysis, and scientific programming.

Requirements

• Full-time, 12-month position with possibility of renewal.
• Remote work option.

Company Description

Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.